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Ozempic Weight Loss

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Summary

Ozempic is an FDA-approved prescription diabetes medication for improving blood sugar levels in adults with type 2 diabetes, but it can also be prescribed off-label for weight loss. The active ingredient in Ozempic, semaglutide, is a GLP-1 receptor agonist that helps control blood glucose levels and has been shown to lead to a significant reduction in body weight.

Common side effects of Ozempic include nausea, vomiting, diarrhoea, constipation, and abdominal pain. These can be managed by gradually increasing the dosage and adjusting meal choices. Ozempic is administered by a weekly injection and is most effective when combined with a healthy diet and regular physical activity for weight loss.

What is Ozempic

Ozempic is an FDA-approved prescription medication designed to improve blood sugar levels for adults with type 2 diabetes. The active ingredient, semaglutide, is a GLP-1 receptor agonist that works by activating the GLP-1 receptors throughout the body and boosting the release of insulin from the pancreas. This action helps to improve blood glucose levels and lower hemoglobin A1C levels over time, while also lowering the risk of cardiovascular events such as stroke or heart attack for those with known heart disease. In addition to providing better glucose control, Ozempic has been shown in clinical trials to lead to significant weight loss and lower blood pressure – an additional benefit for those struggling with their weight management. 

 

Ozempic and weight loss

As Ozempic contains semaglutide, a GLP-1 agonist that increases the effects of the  GLP-1 hormone. This impactful hormone helps to contribute to those looking to lose body weight in two ways: first, it slows gastric emptying, causing feelings of fullness after meals and reducing the amount of food needed for satisfaction; and second, it tells your brain when you’re full so that you stop eating before consuming too many calories. The FDA recently approved semaglutide for weight loss under the brand name Wegovy with a higher dose than that provided by Ozempic. Despite Ozempic being originally prescribed to treat people with type 2 diabetes, it can now be prescribed off-label for weight loss.

 

In a Once-Weekly Semaglutide in Adults with Overweight or Obesity trial, 1961 adults with a body-mass index of 30 or greater (≥27 in persons with ≥1 weight-related coexisting condition), who did not have diabetes, and were randomly assigned, a 2:1 ratio, to 68 weeks of treatment with once-weekly subcutaneous semaglutide (at a dose of 2.4 mg) or placebo, plus lifestyle intervention.

In the semaglutide group, the average change in body weight from the starting point to week 68 was a decrease of 14.9%, whereas, in the placebo group, it was a decrease of 2.4%.

Furthermore, a higher number of participants in the semaglutide group achieved weight reductions of 5% or more (86.4% vs. 31.5%), 10% or more (69.1% vs. 12.0%), and 15% or more (50.5% vs. 4.9%) at week 68, compared to the placebo group. The actual change in body weight from the starting point to week 68 was a decrease of 15.3 kg in the semaglutide group, while it was a decrease of 2.6 kg in the placebo group. 

 

Who is eligible for Ozempic 

Ozempic is only approved by the FDA for the treatment of type 2 diabetes. People who don’t have diabetes may be able to take Ozempic off-label with a prescription from their healthcare provider. Finding a healthcare provider who will prescribe Ozempic if you do not have diabetes is getting increasingly difficult, as many people have been able to do this recently, but it is causing a shortage of the drug. 

 

Is Ozempic Safe? Common Side Effects of Ozempic.

You should only be prescribed Ozempic as a weight loss medication if your healthcare professional knows and understands your health history, health goals, lifestyle, and family history. There is nothing inherently bad about taking Ozempic if you do not have diabetes, it doesn’t work like insulin, which can be dangerous if taken without diabetes.

While Ozempic is safe, it can come with some unwanted side effects like most GLP-1-based weight loss drugs; these include nausea, vomiting, diarrhoea, constipation and abdominal pain. Although these symptoms can be bothersome for many people taking these medications, there are ways of mitigating them. Gradually increasing medication dosage and ensuring that meals are eaten at regular intervals (avoiding high-fat foods) can help reduce the intensity of any uncomfortable gastrointestinal side effects. Some rarer side effects can be an increased risk of medullary thyroid carcinoma ( a type of thyroid cancer ) If you feel like you’ve had an allergic reaction, you must contact your health care provider

 

How to take Ozempic for weight loss

You need to inject the prescription drug once a week in your thigh, abdomen or upper arm. When starting for the first time, you will need to take a single dose of 0.25mg, after week 5, your healthcare team will increase your single dose to 0.5mg, this will be your maintenance dose.  For maximum weight loss results, it’s recommended to pair the medication with a healthy diet and regular physical activity.  

Further reading about Ozempic