Saxenda vs Wegovy

Saxenda vs Wegovy

Saxenda and Wegovy, both developed by Novo Nordisk, are GLP-1 agonist medications recommended for individuals struggling with chronic weight management. They are typically prescribed in conjunction with healthy dietary habits and physical activity measures to individuals dealing with obesity (BMI of 30 or higher) as well as those who are overweight (BMI of 27 or higher) and are contending with weight-related health conditions such as type 2 diabetes, hypertension, or elevated cholesterol levels.

Wegovy and Saxenda are two separate weight-loss medications with distinct active ingredients. While Saxenda contains liraglutide, Wegovy contains semaglutide. The use, dose, and potential weight loss results can all be different between the two drugs. There has been a great deal of media attention surrounding a drug called ‘Ozempic’ which is also known to contain semaglutide and which is approved for managing blood sugar levels in patients with type 2 diabetes; however, Wegovy will be the first injection specifically marketed as a weight loss solution. In a comparative clinical trial between liraglutide and semaglutide, individuals using Wegovy experienced an average weight loss of nearly 16%, whereas those using Saxenda achieved a loss of over 6% body weight.

The difference between Wegovy and Saxenda could confuse those considering either injection for weight loss purposes. It’s important to understand the differences between both active ingredients before committing to any type of drug regimen so that you can ensure the best possible result from your chosen treatment. Additionally, it is important to consult with your primary healthcare provider before selecting traditional or alternative treatments for any medical condition.

 

Side Effects

Saxenda

 

Most common

  • Nausea, vomiting, and stomach pain
  • Diarrhea
  • Constipation
  • Fast heart rate
  • Tiredness
  • Headaches and dizziness

More serious

  • Increased heart rate
  • Suicidal thoughts or sudden changes in behavior and mood
  • Severe nausea, vomiting, or diarrhea that will not stop
  • Hypoglycemia (very low blood sugar levels) – feeling very weak, shaking, confused, sweating, fainting, or seizures
  • Pain or difficulty urinating, swelling in ankles or feet, tiredness, and difficulty breathing
  • Trouble swallowing, lump, or swollen neck
  • Jaundice – yellowing of eyes or skin, darker stools, upper stomach pain spreading to the back

Wegovy

 

Most common

  • Nausea, vomiting
  • Diarrhea, constipation, abdominal pain
  • Headache, dizziness
  • Fatigue
  • Dyspepsia, abdominal distension, eructation
  • Hypoglycemia in patients with type 2 diabetes
  • Flatulence, gastroenteritis, and gastroesophageal reflux disease

More serious

  • Thyroid C-cell tumors
  • Acute pancreatitis
  • Acute gallbladder disease
  • Acute kidney injury
  • Hypersensitivity
  • Diabetic retinopathy complications in patients with Type 2 Diabetes
  • Heart rate increase
  • Suicidal behavior and ideation
Medication delivery Daily injection.
Use provided ‘pen’ to inject into thigh, stomach, upper arm
Weekly injection.
Use provided ‘pen’ to inject into the thigh, stomach, upper arm
Medication Name
Saxenda
(Liraglutide)
Wegovy
(Semaglutide)
Monthly Cost
£299
£199
How the medication works
Suppresses appetite and slows gastric emptying
Suppresses appetite and slows gastric emptying
Licensed for weight loss
Yes
Yes
Dose schedule
Increase dose weekly from 0.6mg through 1.2mg, 1.8mg, 2.4mg to maximum 3.0mg from week 5
Increase the dose monthly from 0.25mg, 0.5mg, 1mg, and 1.7mg then the maximum dose of 2.7mg from month 5
BMI eligibility
30+ or 27+ with comorbidity
30+ or 27+ with comorbidity
Weight loss efficacy
* * * *
* * * * *
Common Side effects
Nausea and mild gastrointestinal discomfort
Nausea and mild gastrointestinal discomfort