£75 off your first month

Semaglutide: How it Works & Why it Results in Weight Loss

Medically reviewed by

Prof Rishi Singhal MBBS, MRCS, FRCS, MD

overweight woman measuring waistline, diabetes

Semaglutide is a drug you may have heard frequently in the headlines for its power to help individuals lose weight. It was originally developed as a treatment for type 2 diabetes when it was discovered to have other significant effects. This being that it caused a decrease in patients’ body weight.  

How does it work for weight loss? Let’s take a closer look…

Semaglutide is a GLP-1 receptor agonist, which essentially means it mimics the action of a hormone we have in our body, called ‘glucagon-like peptide’ (GLP-1). This hormone, like most, is naturally produced by our body as a response to the intake of food. It is produced so your blood sugars can remain level, by triggering the release of insulin from your pancreas. Additionally, GLP-1 slows down the rate at which the food you have eaten empties from the stomach. As you can imagine, this makes you feel fuller for longer, which starts to reveal how Semaglutide will help you lose weight.  

Let's look further into this…

As briefly mentioned, Semaglutide works in very similar ways to GLP-1 which is naturally formed by the body. Let’s think about it this way, if your body is receiving more of the Semaglutide, you will feel fuller for longer. It also increases your insulin levels and reduces the production of glucose which helps restrict you from feeling hungry. To further expand on this, Semaglutide is longer lasting and stronger, compared to the natural GLP-1 that your body secretes.  

Based on these statistics, the injection is administered once a week to help regulate a patient’s blood sugar levels and reduce the rate at which food leaves the stomach. As a result of this, the patient will have increased feelings of fullness and a reduced appetite.  


It’s important to note that Semaglutide isn’t a magic pill for weight loss. It’s most effective when combined with exercise and better eating habits. It is also not recommended for everyone; it should only be used by adults who have a BMI of 27 or higher.  

Like any medication, Semaglutide does have side effects. The most common side effects include nausea, heartburn, and diarrhoea. However, these usually go away within the first few days or weeks.  

To conclude

To conclude, Semaglutide is a promising medication for weight loss and can help individuals who are struggling with losing weight by themselves, by mimicking hormones that naturally produce in the body. with that being said, it does have side effects that can be inconvenient in everyday life. However, these often fade over time.  

For more information regarding Semaglutide and weight loss pens, please get in touch